Si è tornati a salire alla Vuelta e Sepp Kuss ha avuto gioco facile nel difendere la maglia rossa per la quarta giornata consecutiva. All'indomani della cronometro individuale, l'11a frazione proponeva un duro arrivo in salita a Laguna Negra dopo i 163km partiti da Lerma e i vari rivali dello statunitense non sono riusciti a trovare lo spunto necessario per rosicchiare secondi preziosi in classifica generale. Il corridore della Jumbo-Visma mantiene dunque 26" su Marc Soler e 1'09" su Remco Evenepoel.
La tappa è stata vinta dallo spagnolo Jesus Herrada che, a 250m dal traguardo, ha avuto il guizzo giusto per battere la concorrenza degli altri sette battistrada rimasti dopo la lunga fuga di giornata. Alle sue spalle sono giunti il francese Romain Grégoire a 3" e il danese Andreas Kron a 8", mentre gli uomini di classifica sono arrivati attardati di 5'50".
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