Niente da fare per le due favorite del torneo, che a Cincinnati si sono viste negare la possibilità di accedere all'ultimo atto. Nella prima semifinale è stata Iga Swiatek (WTA 1) ad aver dovuto fare prematuramente le valigie. La polacca è stata infatti eliminata da Coco Gauff (7) per 7-6 (7/2) 3-6 6-4 in 2h52' di gioco. Dopo un primo set vinto al tie-break dalla statunitense, la numero 1 al mondo è stata capace di conquistare due break e fare suo il secondo parziale. Purtroppo non abbastanza per lei, con la padrona di casa che nell'ultimo set ha chiuso la partita sfruttando il quarto match point a sua disposizione.
Nella seconda semifinale è stata invece Aryna Sabalenka (2) a capitolare sotto i colpi di Karolina Muchova (17), capace in 2h39' di vincere col punteggio di 6-7 (4/7) 6-3 6-2. A nulla è servito il primo set vinto al tie-break dalla bielorussa, incapace di ripetersi nei due parziali successivi.
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