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La ricercatrice Sara Montagner ha ricevuto il Premio Marie Heim-Vögtlin del Fondo nazionale svizzero, di 25'000 franchi, per il suo lavoro sulla funzione delle cellule immunitarie all'Istituto di ricerca in biomedicina (IRB) di Bellinzona.
La biologa, nell'ambito del suo post dottorato all'IRB tra il 2016 e il 2017, ha dimostrato l'influenza fondamentale dell'epigenetica sulla fisiologia dei mastociti e, di conseguenza, sulla nostra salute.
I cambiamenti epigenetici nel DNA giocano un ruolo determinante nel normale funzionamento dei mastociti, ovvero delle cellule che assumono compiti importanti nelle reazioni immunitarie e nella difesa da agenti patogeni. Tuttavia, se i mastociti reagiscono in modo eccessivo, possono svilupparsi sintomi allergici.
Montagner, insieme a altri ricercatori, ha osservato che le funzioni dei mastociti sono state alterate in assenza di due enzimi, TET2 e DNMT3A, mostrando una maggiore proliferazione e rilasciando quantità eccessive di sostanze che hanno innescato reazioni immunitarie.
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